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structure nameCRYSTALLOGRAPHIC ANALYSIS OF THE INTERACTION OF THE GLUCOCORTICOID RECEPTOR WITH DNA
(PROTEIN GLUCOCORTICOID RECEPTOR)
referenceOtwinowski et al. Nature 352 497 1991
sourceRattus norvegicus
experimentX-ray (resolution=2.90, R-factor=0.196)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes1glu_AB 1r4o_AB 1r4r_AB 3fyl_AB 3g6p_AB 3g6q_AB 3g6r_AB 3g6u_AB 3g8u_AB 3g8x_AB 3g97_AB 3g99_AB 3g9i_AB 3g9j_AB 3g9m_AB 3g9o_AB 3g9p_AB 5va0_AB 5va7_AB 6bse_AB 6x6d_AB 6x6e_AB
reference complex3g9m_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKVRK

Estimated binding specificities ?

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# IC=4.007 IC/col=0.668 n_of_columns=6 specificity:   
A |  67   9  24  67   0  96
C |  11   9  24  11  96   0
G |   9  69  24   9   0   0
T |   9   9  24   9   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----KGVT--RGKC--   L                   +-1glu_A    
                           +-------------3 
  --ECKG--RGRG--FT   L     !             +-3dzy_D    
                           ! 
  ----KGVG--RG----   L   +-7               +4tnt_B    
                         ! !    +----------1 
  --ECKG--KGRG----   L   ! !    !          +3e00_A    
                         ! +----6 
  --ECKG--KGRA----   L   !      !   +------5l0m_A    
                         !      +---5 
  --EAKG--RTRG----   L --8          !   +--1kb2_B    
                         !          +---4 
  ----KGVT--RG----       !              ! +5emc_A    
                         !              +-2 
  CAECKG--KGRG----   L   !                +6l6q_B    
                         ! 
  --DAKG--RGRG----   L   +----------------4iqr_B

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updated Mon Dec 16 17:51:21 2024