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structure nameIRF4 TRANSCRIPTION FACTOR MUTANT -K59R
(ICSAT transcription factor)
referenceCasarotto et al.
sourceHomo sapiens
experimentX-ray (resolution=2.47, R-factor=0.205)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInterferon regulatory factor transcription f;
multimeric complexes7jm4_GH 7o56_AB 7ogs_AB 7ogs_EF 7oot_AB 7rh2_GH 8jkl_CD 8jkl_GH 8jkq_DG 8jkq_FH 8jks_CD 8jks_GH
redundant complexes7jm4
reference complex7oot_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRTRCK

Estimated binding specificities ?

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# IC=4.829 IC/col=0.805 n_of_columns=6 specificity:   
A |   6   6  72  78  78   0
C |   6   0   6   6   6  96
G |   6  84  12   6   6   0
T |  78   6   6   6   6   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  HTLT------RTNTRGSTAT--RT------       +-----------------------------1t2k_B    
                                       ! 
  HC----------NTRGCT--NGST------   L   !                +------------1if1_B    
                                       !           +----4 
  ----ECKT--RGAT--RGNT----------   L   !           !    !           +1pue_E    
                                     --7           !    +-----------3 
  ----DCKT--RG----RGYA----------   L   !           !                ! +1dux_F    
                                       ! +---------5                +-2 
  ------KT--RGAT--RGYA----------   L   ! !         !                  +4iri_A    
                                       ! !         ! 
  ------STVT------RGQTNTMT------   L   +-6         !                 +5d5v_B    
                                         !         +-----------------1 
  ------ST--------RTQT----KG----         !                           +5d5w_B    
                                         ! 
  --------------------------YGKC   L     +---------------------------6lui_A    
                                     

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updated Fri Sep 13 07:30:18 2024