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structure nameCRYSTAL STRUCTURE OF HETERODIMERIC ECDSYONE RECEPTOR DNA BINDING COMPLEX
(RETINOIC ACID RECEPTOR RXR-ALPHA)
referenceDevarakonda et al. 'Embo 22 5827 2003
sourceHOMO SAPIENS
experimentX-ray (resolution=2.60, R-factor=0.233)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes1by4_BC 1dsz_AB 1r0n_AB 1ynw_AB 2nll_AB 4cn2_CD 4cn3_AD 4cn3_BC 4cn5_AB 4cn7_AB 4cn7_EF 6fbq_AB 6fbr_AB 6xwg_CD 6xwh_CD 8hbm_AB 8hbm_EF
reference complex6fbq_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKKR

Estimated binding specificities ?

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# IC=4.250 IC/col=0.850 n_of_columns=5 specificity:   
A |   0   0  60   0  12
C |   0   0  12  96  60
G |   0  84  12   0  12
T |  96  12  12   0  12
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Dendrogram of similar interfaces ?

matrix format
  
  ----EAKG--RTRG----   L                           +1kb2_B    
                                       +-----------8 
  --CAECKG--KGRG----   L          +---14           +6l6q_B    
                                  !    !  
  ----ECKG--KGRG----   L          !    +------------3e00_A    
                                  !  
  ----ECKG--KGRG----   L          !                 +1r0n_A    
                                  !             +---6 
  ----ECKG----RA----   L          !             !   +5krb_G    
                                  !             !  
  ------KAVA--RA----   L   +-----15       +----11   +5e69_A    
                           !      !       !     ! +-2 
  ------KGVT--RG----   L   !      !       !     ! ! +5cbz_E    
                           !      !       !     +-9 
  ------KAVG--RG----       !      !       !       !   +5va7_A    
                           !      !       !       ! +-3 
  ------KGVT--RG----       !      !       !       +-5 +5emc_A    
                           !      !       !         ! 
  ----ECKG--KGRG----   L   !      +------13         +4nqa_H    
                           !              !  
  ST--ECKG--KGRG----   L   !              !           +6fbq_A    
                         -16              !        +--1 
  ----EAKG--RTRTRT--       !              !        !  +4umm_E    
                           !              !  +----10  
  ----ECKG--KGRG----   L   !              !  !     !  +1ynw_B    
                           !              !  !     +--7 
  ----ECKG--RGRG----   L   !              +-12        +3dzy_D    
                           !                 !  
  ------KGVG--RG----   L   !                 !        +4tnt_B    
                           !                 +--------4 
  ------KGVT--RG----   L   !                          +1glu_A    
                           !  
  ----DAKG--RGRG--RT   L   +------------------------4iqr_B    
                         

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updated Thu Sep 12 15:23:53 2024