| structure name | CRYSTAL STRUCTURE OF THE HUMAN RETINOID X RECEPTOR DNA-BINDING DOMAIN BOUND TO THE HUMAN MEP DR1 RESPONSE ELEMENT, PH 7.0 (Retinoic acid receptor RXR-alpha) |
| reference | Poussin-Courmontagne et al. 'Mol. 481 44 2019 |
| source | Homo sapiens |
| experiment | X-ray (resolution=1.60, R-factor=0.164) |
| structural superfamily | Glucocorticoid receptor-like DNA-binding domain; |
| sequence family | Zinc finger, C4 type two domains; |
| multimeric complexes | 1by4_BC 1dsz_AB 1r0n_AB 1ynw_AB 2nll_AB 4cn2_CD 4cn3_AD 4cn3_BC 4cn5_AB 4cn7_AB 4cn7_EF 6fbq_AB 6fbr_AB 6xwg_CD 6xwh_CD 8hbm_AB 8hbm_EF 8j54_CD 8j54_EF |
| redundant complexes | 1by4_A
1r0n_A
 4cn2_D
4cn5_B
4cn7_A
6fbr_B
6xwg_C
6xwh_C
8j54_C
1dsz
1ynw
2nll
4cn3
8hbm
|
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | SEKKRR |
Estimated binding specificities ?
| readout + contact |  |
A | 7 0 73 0 0 7 75 C | 9 0 7 96 96 75 7 G | 7 96 9 0 0 7 7 T | 73 0 7 0 0 7 7scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: RXR | ||
| AGGTCA | PubMed | 6fbq_A(6.73e-05), 1dsz_AB(1.67e-04), 1r0n_AB(1.09e-04), ... (total=15) |
| GGGTCA | PubMed | 6fbq_A(2.51e-08), 1dsz_AB(1.08e-07), 1r0n_AB(1.09e-04), ... (total=13) |
Dendrogram of similar interfaces ?
matrix format--EAKG--KTRG-- L +-----------------------------4umm_A ! CAECKG--KGRG-- L ! +----1cit_A +-4 +------------1 ----KGVT--RG-- L ! ! +---2 +----2c7a_B ! ! ! ! --ECKGAG--RG-- L --5 +-------3 +-----------------4ond_A ! ! --ECKGAG--KTRG L ! +---------------------4aa6_B ! --ECKGAGKGRG-- L +-----------------------------1hcq_E |
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updated Sat Jan 10 10:07:13 2026