| structure name | CRYSTAL STRUCTURE OF THE HUMAN RETINOID X RECEPTOR DNA-BINDING DOMAIN BOUND TO THE HUMAN MEP DR1 RESPONSE ELEMENT, PH 7.0 (Retinoic acid receptor RXR-alpha) |
| reference | Poussin-Courmontagne et al. 'Mol. 481 44 2019 |
| source | Homo sapiens |
| experiment | X-ray (resolution=1.60, R-factor=0.164) |
| structural superfamily | Glucocorticoid receptor-like DNA-binding domain; |
| sequence family | Zinc finger, C4 type two domains; |
| multimeric complexes | 1by4_BC 1dsz_AB 1r0n_AB 1ynw_AB 2nll_AB 4cn2_CD 4cn3_AD 4cn3_BC 4cn5_AB 4cn7_AB 4cn7_EF 6fbq_AB 6fbr_AB 6xwg_CD 6xwh_CD 8hbm_AB 8hbm_EF |
| redundant complexes | 1by4_A
1r0n_A
4cn2_D
4cn5_B
 4cn7_A
6fbr_B
6xwg_C
6xwh_C
1dsz
1ynw
2nll
4cn3
8hbm
|
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | SEKKRR |
Estimated binding specificities ?
| readout + contact |  |
A | 6 6 0 0 6 0 78 24 24 6 C | 6 6 0 0 6 96 6 24 24 6 G | 6 78 96 96 6 0 6 24 24 78 T | 78 6 0 0 78 0 6 24 24 6scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: RXR | ||
| AGGTCA | PubMed | 6fbq_A(6.73e-05), 1dsz_AB(1.67e-04), 1r0n_AB(1.09e-04), ... (total=15) |
| GGGTCA | PubMed | 6fbq_A(2.51e-08), 1dsz_AB(1.08e-07), 1r0n_AB(1.09e-04), ... (total=13) |
Dendrogram of similar interfaces ?
matrix format--EAKG--RTRTRT-- +4umm_E +----1 --EAKG--RTRTRT-- +-----------2 +2han_B ! ! --ECKG--KGRG---- +-5 +----3dzy_A ! ! CAECKG--KGRG---- L ! ! +----6l6q_B --6 +-----------3 --ECKG--RGRG--FT L ! +----3dzy_D ! --ECKG--KGRG---- L ! +-------2ff0_A +---------4 ----KGVT--RG---- +-------5emp_A |
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updated Tue Dec 19 12:49:34 2023