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structure nameCRYSTAL STRUCTURE OF VITAMIN D RECEPTOR AND 9-CIS RETINOIC ACID RECEPTOR DNA-BINDING DOMAINS BOUND TO A DR3 RESPONSE ELEMENT
(RETINOIC ACID RECEPTOR RXR-ALPHA)
referenceShaffer et al. 'J.Steroid 89-90 215 2004
sourceHOMO SAPIENS
experimentX-ray (resolution=3.00, R-factor=?)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes1ynw_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKKR

Estimated binding specificities ?

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# IC=4.516 IC/col=0.903 n_of_columns=5 specificity:   
A |  13   0  13   0  96
C |  13   0  13  96   0
G |  57  96  13   0   0
T |  13   0  57   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----EC--KA--RGRG----   L   +-----------------------------4nqa_I    
                             !  
  ----EC--KG--KGRG----   L   !     +---------------------------2ff0_A    
                             !     !  
  ----EC--KG--RGRG----   L   !     !                           +2nll_B    
                             !     !             +-------------3 
  ----EA--KG--RTRG----   L   !     !             !             +1kb2_B    
                             !     !             !  
  --HGECAGKGAAKGRT----   L   !     !             !        +----1lo1_A    
                             !     !          +-15        !  
  --------KGVT--RG----       !     !          !  !    +--13    +1r4i_A    
                             !     !          !  !    !   !  +-7 
  ----ET--KGAT--RG----   L   !     !          !  !    !   +-10 +1lat_A    
                             !     !          !  !    !      !  
  ----EC--KG--KTRG----   L -21  +-19          !  +---14      +-2nll_A    
                             !  !  !          !       !  
  ----EC--KG--RGRG----   L   !  !  !          !       !         +1dsz_A    
                             !  !  !     +---16       !       +-4 
  ----EA--KG--KTRG----   L   !  !  !     !    !       +-------8 +2han_A    
                             !  !  !     !    !               ! 
  --------KGVT--RG----   L   !  !  !     !    !               +5cbz_E    
                             !  !  !     !    !  
  ----EC--KG--KGRG----   L   !  !  !     !    !                +1ynw_B    
                             !  !  !     !    !              +-5 
  ----EC--KG----RA----   L   !  !  !     !    !              ! +5krb_G    
                             !  !  !     !    +--------------9 
  --------KGVT--RG----   L   !  !  +----18                   ! +6x6e_A    
                             !  !        !                   +-6 
  ----EC--KG--RGRG----   L   +-20        !                     +3dzy_D    
                                !        !  
  CA--EC--KG--KGRG----   L      !        !                  +---6l6q_B    
                                !        !  +--------------12  
  ----DG--KG--RTRG----   L      !        !  !               !   +3cbb_A    
                                !        !  !               +---1 
  ----EC--KG--KGRG----          !        !  !                   +3dzy_A    
                                !        +-17  
  --HC----KGVT--RG--RT          !           !                   +3g9m_B    
                                !           !               +---2 
  ----EA--KG--RTRTRT--          !           +--------------11   +4umm_E    
                                !                           !  
  ----EC--KGAG--RG----   L      !                           +---4ond_A    
                                !  
  ----EC--KG--RGRG----   L      +----------------------------5uan_B    
                           

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updated Thu Dec 22 18:02:28 2022